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Ketamine Clinical Trials

Improving the ways we put patients to sleep (anaesthesia) for weight loss surgery

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Id: ACTRN12620000198921p

Organisation Name: Department of Anaesthesia

Overal Status: Not yet recruiting

Start Date: 06/04/2020

Brief Summary: Obesity is a major public health problem in both the developed and the developing world. A therapeutic approach that includes both bariatric surgery and medical management is more effective than medical management alone. However, bariatric patients are more prone to post operative complications that include post operative nausea and vomiting (PONV) and obstructive sleep apnea (OSA) both of which are caused by opiate administration. Despite the potential for both total intravenous anaesthesia (TIVA) and lignocaine infusions to reduce both of these morbidities there are few published reports in the literature on their use in bariatric patients. We propose to perform a pilot study in which patients are randomised to opiate free TIVA (Dexmedetomidine, Ketamine, Lignocaine and Propofol) or standard volatile-opiate based general anaesthesia and post operative care. We postulate that opiate free TIVA will provide improved analgesia, reduce PONV, cause less respiratory adverse events and lead to better post surgical rehabilitation. Ultimately we seek to establish a program of research which assesses the best method of Anaesthesia in Bariatric Patients. Pilot data will be used in grant applications to the Australian and New Zealand College of Anaesthetists (ANZCA) and the National Health and Medical Research Council (NHMRC).

  • Australia
  • Obesity
  • Post operative pain
  • Post Operative Nausea and Vomiting
  • Post Operative Acute Rehabilitation
  • Opiate Free Total Intravenous Anaesthesia

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