Ketamine molecule:

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Ketamine Clinical Trials

The effect of methamphetamine and alcohol on cognition and driving performance.

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Id: ACTRN12618000629235

Organisation Name: Swinburne University of Technology

Overal Status: Recruiting

Start Date: 25/06/2018

Brief Summary: Amphetamine-type substances, especially d-methamphetamine, are second only to alcohol for incurred personal, economic and societal burden. Both alcohol and methamphetamine produce impairments in many areas of cognitive/neurobehavioural functioning which are also observed under complex driving conditions, and these two drugs are detected in as many as one-third of drivers injured and killed in road traffic accidents. No controlled experimental research is available which assesses performance on these tasks when alcohol and methamphetamine are used in combination, and importantly, how these deficits may translate into increased crash risk.

This trial aims to assess the direct effect of combined usage of low (legal) doses of alcohol combined with d-methamphetamine in measures of higher-order cognitive and neurobehavioural functioning, driving performance and ocular activity. This will be achieved through a within-subjects, double-blind, placebo-controlled design comprising four experimental sessions [alcohol (placebo: 0.00% BAC; active: 0.04% BAC) and d-methamphetamine (0.42mg/kg, placebo; active).

This project will provide vital information of how several behavioural, cognitive, neurobehavioural and physiological indices are affected following combined
alcohol and methamphetamine use, and will show the effect of these combined drugs on driving performance and accident risk.

  • Australia

Total execution time in seconds: 0.36808204650879