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Ketamine Clinical Trials

Comparison between ketamine and dexmedetomidine as adjuvants in Pectoral Nerves Regional Blocks for perioperative pain control for patients undergoing breast cancer surgery

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Id: ACTRN12617000851369

Organisation Name: Amira Soliman

Overal Status: Withdrawn

Start Date: 20/06/2017

Brief Summary: Significant postoperative pain can follow major surgical procedures for cancer breast . postoperative pain that not well controlled has a lot of negative consequences as the patient sufferings, more hospital costs with extended hospital stay, and it is a risk factor in the development of chronic post-mastectomy pain .Procedural interventions involving regional blocks are found to be more effective than pharmacologic means .Pecs 1 and 2 can provide effective postoperative analgesia for such procedures . Pecs 1 and 2 blocks are field blocks that aim to deposit the local anesthetic between the pectoralis major and minor muscles and between pectoralis minor and serratus anterior respectively to block the different peripheral nerves supplying breast and so providing complete analgesia for breast surgery . Dexmetomedine an alpha2 receptor agonist has been used as an adjuvant to local anesthetic for various regional anesthetic techniques with significant prolongation of duration of analgesia . Ketamine a N-methyl-D-aspartate receptor antagonist has a reported local anesthetic and analgesic properties .Studies on caudal administration of ketamine combined with the local anesthetic has shown that it is effective for prolonging the duration of postoperative analgesia. Very few studies about the efficacy of ketamine for prolonging the duration of analgesia when combined with local anesthetic for peripheral nerve blocks with different conclusions.
Therefore our study was planned to compare the analgesic efficacy and safety of ultrasound guided Pecs 1 and 2 blocks with local bupivacaine versus bupivacaine added to either ketamine or dexmetomidine in patients undergoing breast cancer surgery.

  • Saudi Arabia
  • Egypt

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