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Ketamine Clinical Trials

What is the difference in the safety of Ketamine versus Propofol when used to sedate Acute Psychiatric/ Psychotic Patients who require Aeromedical Retrieval?

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Id: ACTRN12616001134415

Organisation Name: CareFlight Limited

Overal Status: Recruiting

Start Date: 01/09/2016

Brief Summary: The inherent dangers of the aviation environment combined with the potential and unpredictable behaviour of acute psychiatric patients presents a challenge to even the most experienced aeromedical retrieval clinician. An efficacious sedation drug is vital in this environment to ensure crew and patient safety and to minimise patient distress.
The incidence of psychiatric patients requiring retrieval from remote areas is increasing. Over a period of two years and nine months, CareFlight Northern Territory Operations has retrieved 660 psychiatric patients (01/02/2012 – 20/11/2014). There is no consensus on the optimal sedative to us in these patients. There has been no research undertaken that compares Ketamine and Propofol sedation in the aeromedical retrieval of acute psychiatric patients.

Ketamine and Propofol are currently used within CareFlight Northern Territory Operations to sedate acute psychiatric patients who require aeromedical retrieval from their rural and remote areas. The primary purpose is to compare the safety and efficacy of sedating acute psychiatric patients with either Ketamine or Propofol whilst documenting and treating any potential complications that may arise.
This study will also add to the paucity of literature on sedation methods for acute psychiatric patients requiring aeromedical retrieval.

Study Hypothesis: Ketamine and Propofol are both as safe and efficacious as each other in sedating acute psychiatric patients who require aeromedical retrieval

  • Australia
  • Suicidal Ideation
  • Depression
  • Acute Psychosis
  • Schizophrenia
  • Attempted Suicide
  • Post Natal Depression
  • Self Harm
  • Personality Disorder
  • Bipolar Disorder

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