Ketamine Clinical Trials
Effect of Ketamine on Proinflammatory and Anti-inflammatory cytokine response in Pediatric cardiac surgery.
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Organisation Name: Tamer Hamed Aly Ibrahim
Overal Status: Completed
Start Date: 14/05/2015
Brief Summary: Corrective surgery for congenital heart defects in children frequently requires cardiopulmonary bypass (CPB). The combination of anesthesia, surgical stress and CPB evokes an acute systemic inflammatory response with activation of cellular and humoral cascades. This response activates pathways that can lead to organ failure, which increases post-operative morbidity.Countries
The inflammatory response to CBP is often evaluated by means of inflammatory markers in the peripheral blood such as cytokines, acute phase proteins and white blood cells. The most important cytokines in relation to cardiac surgery are tissue necrosis factor 8 ( TNF 8), Interleukin(IL)-6, IL-8 and IL-10.
Ketamine possesses several anti-inflammatory properties. It reduces neutrophil integrin expression and leucocyte-endothelial interaction and also inhibits monocyte and macrophage function. ketamine attenuates the in vitro synthesis of pro-inflammatory cytokines such as TNF8, Il-6 and IL-8 in the blood.
In this study we will examine the effect of ketamine on the inflammatory response in pediatric patients undergoing on-pump cardiac surgery for congenital heart defects. We will also examine if this affects the need and the duration of inotropic drugs infusion and the length of ICU and hospital stay.
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