Ketamine Clinical Trials
Prospective Evaluation of the Clinical Utility of Ketamine in Pain Desensitisation in Chronic Pain
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Id: ACTRN12613000022763
Organisation Name: Monash University
Overal Status: Not yet recruiting
Start Date: 04/02/2013
Brief Summary: The benefits of an existing inpatient treatment regimen involving ketamine infusion for the purpose of pain desensitisation/opioid detoxification will be documented. A sample of approximately 40 female chronic pain patients with either multiple sclerosis (n=20) or complex regional pain (n=20) will be evaluated before and after a 5-day inpatient ketamine infusion procedure (termed “Burst Ketamine”). The procedure itself involves the patient receiving an intravenous infusion of ketamine, administered within a subanaesthetic dose range, whilst an opioid is concurrently given. The endpoints of interest include patient pain thresholds (evaluating the degree of hypersensitivity/allodynia before and after the ketamine protocol), sensitivity to opioid analgesia, quality of life measures, mental health assessment, sleep quality and cognitive processing measures. Additionally, these endpoints will also be assessed in healthy female volunteer participants (n=20) to provide normative comparisons for which the pain patients can be compared against. Collectively, the pre- and post-treatment measures will enable us to determine whether: 1) ketamine therapy increases pain thresholds in patients, 2) ketamine therapy normalises sensitivity to opioids, 3) quality of life, mental health, sleep quality and cognitive measures improve subsequent to ketamine therapy.
Countries:
Conditions:
- Multiple Sclerosis
- Complex Regional Pain Syndrome
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