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Ketamine Clinical Trials


Is one year mortality and morbidity influenced by anaesthesia after major surgery? A Pilot Study


To see complete record on anzctr.org.au, please visit this link

Id: ACTRN12610000668000

Organisation Name: Dr Timothy Short

Overal Status: Completed

Start Date: 05/07/2010

Brief Summary: Recently five overseas studies have found an association between deep anaesthesia and subsequent mortality within one year. There is a need for a large prospective randomised trial of "deep" versus "light" anaesthesia to determine if the relationship is a causal one. This would require the study of about 6000 patients. In this pilot study, 100 patients will be randomised to either "light" or "deep" anaesthesia using the Bispectral Index depth monitor. In all other respects the anaesthesia will be unaltered in choice of anaesthetic drugs or techniques used. We will then follow up all patients for one year to ascertain the incidence of complications of anaesthesia and surgery, cancer recurrence if relevant and survival. The study has the support of the Clinical Trials group of the Australian and New Zealand College of Anaesthetists. If successful, the pilot study will be used as the basis for a large project grant to the Health Research Council in New Zealand (NZ), hopefully combined with an application to the National Health and Medical Research Council in Australia.

Countries:
  • New Zealand
  • Auckland
  • Hong Kong
  • sha tin, new territories
  • Australia


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