Ibogaine molecule:

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Ibogaine Clinical Trials


Preliminar Efficacy and Safety of Ibogaine in the Treatment of Methadone


To see complete record on clinicaltrials.gov, please visit this link

Id: NCT04003948

Organisation Name: International Center for Ethnobotanical Education, Research, and Service

Overal Status: Recruiting

Start Date: October 28, 2020

Last Update: November 4, 2020

Lead Sponsor: International Center for Ethnobotanical Education, Research, and Service

Brief Summary: Methadone is a very long-acting opiate very difficult to detox from. In Spain there are a lot of methadone dependent people in the aftermath of the heroin epidemic of the 1980s. Many have been dependent for more than 15 years and a number of them have a relatively stable life condition (have work, family, housing, etc.) and a relatively good health condition in comparison with current heroin users. This Phase-II RCT is a collaboration with the Sant Joan Hospital in Reus, Spain. Twenty patients on the methadone maintenance program will be recruited. Patients will be randomized to two groups: One receiving 6 doses of 100 mg of ibogaine; and the other one receiving ascending doses of ibogaine (100-200-300-400-500-600). Methadone use will be interrupted and for both groups ibogaine will be administered when clinical symptoms of opioid withdrawal appear. After an ibogaine dose, when symptoms of opioid withdrawal appear again, half of the methadone dose used last time will be administered. By doing so, methadone doses will be progressively reduced until no withdrawal symptoms appear.

Conditions:
  • Drug Dependence
  • Drug Use Disorders
  • Opioid Dependence


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