Dimethyltryptamine molecule:

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DMT Clinical Trials

Effects of Dimethyltryptamine (DMT) in Healthy Subjects: A Placebo-controlled Cross-over Study

To see complete record on clinicaltrials.gov, please visit this link

Id: NCT04353024

Organisation Name: University Hospital, Basel, Switzerland

Overal Status: Completed

Start Date: June 18, 2021

Last Update: October 12, 2022

Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary: N,N-dimethyltryptamine (DMT) is a naturally-occurring psychedelic substance widely used in recreational and spiritual settings. DMT can be used as a tool to induce an altered state of consciousness of interest in psychological and psychiatric research. DMT is rapidly metabolized by monoamine oxidase (MAO) A. Therefore, it is inactive when administered orally and has a very short duration of action when administered parenterally (<20 min).Therefore, an intravenous administration regime including a bolus and maintenance perfusion has been proposed to induce a stable and prolonged DMT experience allowing to study the psychological and autonomic acute effects of DMT. This administration allows to induce and end an altered state safely and quickly. The goal of the present study is to experimentally test different intravenous DMT administration schedules to investigate the subjective and autonomic effects of DMT in healthy subjects.

  • Healthy

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